wxPython is a GUI toolkit for the Python programming language that allows to create robust, highly functional graphical user interface, simply and easily. It is a Python module (native code) that wraps the popular wxWidgets cross platform GUI library.

wxGlade is a GUI designer written in Python with the popular GUI toolkit wxPython, that helps you create wxWidgets/wxPython user interfaces.

PythonCard is a GUI construction kit for building cross-platform desktop applications on Windows, Mac OS X, and Linux, using the Python language and wxPython.

The wxPython tutorial

http://pyserial.sourceforge.net/ - Welcome to pySerial’s documentation.

How do you access the printer from Python under Linux???

How to identify which OS Python is running on? ¹⁾

How can I create a stand-alone binary from a Python script?

PyInstaller is a program that converts (packages) Python programs into stand-alone executables.

cx_Freeze – Create cross platform, stand alone executables from Python scripts and modules.